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Scumlabs is a fictional, transnational corporation of which conduct research in laboratories or bases across the Earth and has been the major antagonist in most games in the Rampage franchise. The staff at Scumlabs are practically rich, but they are characterized by being iniquitous and corrupt businessmen, hellbent upon becoming millionaires through scientific innovations.

Sometimes incidents occur sporadically, resulting in the fabrication of large scale mutants when the Scumlabs staff or civilians come into contact with a radioactive substance, explosion or consumption of impure victuals. Many of these instances occur during an apex of a discovery, the marking of an epoch of good product sales or the reconstruction of every capital or high-rise city.

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