|Brian the Brain Monster|
|Species||Human / Brain Monster|
|First Appearance||Rampage: Total Destruction (2006) (Wii exclusive only)|
Brian is a Brain monster.
He drank Scum Soda and had a violent reaction and turned into a giant brain-like monster.
- Brian, Sarah, Fifi, Plucky, Squirmy, Fabio, Boris and Ruby are the only monsters in Rampage: Total Destruction to not be given descriptions on the official website.
- Brian the Brain could be a tribute to Brian Colin, the original creator of the Rampage series. The developers of Rampage: Total Destruction could consider Brian Colin to be a "genius" for creating Rampage, a substancial reference made by Brian the Brain's large brain.
- Brian makes a striking resemblence to the Martians from the Mars Attacks! franchise. This reference could also be made clear when he "invades" cities.
- In addition, Mitch the Secret Service Agent from Mars Attacks! is acted by Brian Haley. This could meerly be coincidence though.