Brian the Brain Monster
Species Human / Brain Monster
Gender Male
Skin Color Purple
Eye Color White
Speed Mediocre
Jumping Mediocre
Crushing Mediocre
First Appearance Rampage: Total Destruction (2006) (Wii exclusive only)

Brian is a Brain monster.


He drank Scum Soda and had a violent reaction and turned into a giant brain-like monster.


  • Brian, Sarah, Fifi, Plucky, Squirmy, Fabio, Boris and Ruby are the only monsters in Rampage: Total Destruction to not be given descriptions on the official website.
  • Brian the Brain could be a tribute to Brian Colin, the original creator of the Rampage series. The developers of Rampage: Total Destruction could consider Brian Colin to be a "genius" for creating Rampage, a substancial reference made by Brian the Brain's large brain.
  • Brian makes a striking resemblence to the Martians from the Mars Attacks! franchise. This reference could also be made clear when he "invades" cities.
    • In addition, Mitch the Secret Service Agent from Mars Attacks! is acted by Brian Haley. This could meerly be coincidence though.


Rampage GeorgeLizzieRalphLarry (Atari Lynx version only)
Rampage: World Tour GeorgeLizzieRalphV.E.R.N.Eustace DeMonic
Rampage 2: Universal Tour CurtisBorisRubyGeorgeLizzieRalphMyukusPucousNoobus
Rampage Through Time GeorgeLizzieRalphMyukusHarley (Playstation exclusive only) • CurtisBorisRuby
Rampage: Puzzle Attack GeorgeRalphLizzieRubyBorisMyukusCurtisNoobus
Rampage: Total Destruction GeorgeLizzieRalphRamseyGilmanRhettBoris (Wii exclusive only) • Ruby (Wii exclusive only) • CalLeonCrockKyleSquirmy (Wii exclusive only) • Fabio (Wii exclusive only) • MarcoRojoPlucky (Wii exclusive only) • Fifi (Wii exclusive only) • IckyVenusWallyHarryShelbyAmandaNatalieKingstonRockySarah (Wii exclusive only) • Brian (Wii exclusive only) • EdwinJoeBartJackJillNickCyril (Wii exclusive only) • Vern (Wii exclusive only) • PhilbertEyegoreBubba
Rampage GeorgeLizzieRalphUnnamed Robot MonsterUnnamed Tentacled MonsterUnnamed Hunchback MonsterUnnamed Praying Mantis Monster
Rampage (2018 film) GeorgeLizzie† • Ralph† • Unnamed Rat Monster