Brian is a Brain monster.
- Brian the Brain could be a tribute to Brian Colin, the original creator of the Rampage series. The developers of Rampage: Total Destruction could consider Brian Colin to be a "genius" for creating Rampage, a substancial reference made by Brian the Brain's large brain.
- Brian makes a striking resemblence to the Martians from the Mars Attacks! franchise. This reference could also be made clear when he "invades" cities.
- In addition, Mitch the Secret Service Agent from Mars Attacks! is acted by Brian Haley. This could meerly be coincidence though.